Hematology Practice Questions
Hematology covers anemia workup, inherited and acquired bleeding disorders, transfusion reactions, and malignancies. These four sample questions come from MediLingo's bank of 3,900+ questions across 21 specialties.
Sample questions
Question 1
A woman is a known carrier of hemophilia A. What is the probability that each of her sons will have hemophilia?
a) 100 percent
b) 25 percent
c) 50 percent ✓ Correct
d) 0 percent
Key teaching point: A hemophilia carrier mother has a 50 percent chance with each son.
Question 2
Eight days after a packed red cell transfusion, a 52-year-old woman presents with fatigue, jaundice, and a hemoglobin drop from 9.5 to 7.2 g/dL. Direct antiglobulin (Coombs) test is positive and a new alloantibody is identified. What is the diagnosis?
a) Acute hemolytic transfusion reaction
b) Delayed hemolytic transfusion reaction from an anamnestic alloantibody response ✓ Correct
c) Transfusion-related acute lung injury
d) Iron overload from chronic transfusion
Key teaching point: Falling Hb + jaundice + positive DAT 5–14 days post-transfusion = delayed hemolytic reaction (new alloantibody).
Question 3
Why can a normal ferritin not exclude iron deficiency in a patient with active rheumatoid arthritis?
a) Arthritis destroys ferritin
b) Ferritin is only accurate in children
c) Ferritin is an acute-phase reactant that rises with inflammation ✓ Correct
d) Ferritin measures B12 stores
Key teaching point: Ferritin is an acute-phase reactant — never exclude iron deficiency by ferritin alone during active inflammation.
Question 4
A 25-year-old woman with type 1 von Willebrand disease needs a dental extraction. What is the preferred treatment to prevent bleeding?
a) Factor IX concentrate
b) Desmopressin (DDAVP) ✓ Correct
c) Platelet transfusion
d) Warfarin
Key teaching point: Desmopressin is first-line for type 1 vWD bleeding and procedures.
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